Methods Mol Biol. ; doi: /_3. Measuring and Interpreting Serum AAT Concentration. Donato LJ(1), Snyder MR( 2). Relationship of AAT Protein Variants to Serum AAT Levels and Emphysema Risk in Adults. Alpha-1 antitrypsin (AAT) is a protein in the blood that protects the lungs from damage caused by activated enzymes. Laboratory tests measure the level of AAT in blood or identify abnormal forms of AAT that a person has inherited to help diagnose alpha-1 antitrypsin deficiency.
AAT: Workup of individuals with suspected disorders such as familial chronic obstructive lung disease Diagnosis of alphaantitrypsin deficiency. Rationale α1-Antitrypsin (AAT) deficiency is one of the commonest rare respiratory disorders worldwide. Diagnosis, assessment of risk for developing chronic. for COPD is inversely related to the serum AAT level according to the hierarchy PI NullNull > PI ZZ > PI. SZ > PI MZ.1e4 Therefore, accuracy in.
Alphaantitrypsin (AAT) is the chief protease inhibitor (PI) in human serum. The loss of this PI results in the degradation of the connective protein elastin in lung. The most widely available and least expensive specific test for Alpha-1 is the AAT serum level. This test, when performed correctly, can easily detect the most. Alphaantitrypsin or α1-antitrypsin (A1AT, A1A, or AAT) is a protein belonging to the serpin In older biomedical literature it was sometimes called serum trypsin inhibitor (STI, dated terminology), because its capability as a trypsin inhibitor. α1-Antitrypsin (AAT) deficiency is an underrecognized genetic A serum AAT level of 11 μM represents the protective threshold value below.